The receptors for IL-31, IL-31RA, and the receptor for IL-33, ST2, are commonly expressed on dermal fibroblasts, and it is speculated that IL-31 and IL-33 can synergistically stimulate basophils that interact with fibroblasts to release atopic dermatitis (AD)-related chemokines (95). The gene discussed is IL31; the disease is Alzheimer disease.