IL6ST and COVID-19: Consequently, patients with levels of IL-6 signalling variables above cut-offs presented a significant increased risk of developing severe COVID-19 (IL-6: OR 12.59 (5.66 - 28.0); sIL-6R: OR 8.19 (3.60 - 18.61); sgp130: OR 7.69 (3.69 - 16.01)).