Produced in response to TLR activation, interleukin-27 (IL-27) is a cytokine of interest for its activity against viral infection. IL-27 is composed of two subunits, IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3) (4), and signals via a heterodimeric receptor consisting of WSX-1 and glycoprotein (gp130) (5). The gene discussed is IL27RA; the disease is viral infectious disease.