For instance, IL-27 inhibited HIV infection in primary human monocyte-derived DCs and macrophages through induction of several ISGs including MX1, OAS2, OAS3, interferon-induced transmembrane protein 1(IFITM1), IFITM3, radical S-adenosyl methionine domain containing 2 (RSAD2), and PKR, even in the presence of type I IFN neutralizing antibodies (25, 32). Here, RSAD2 is linked to HIV infectious disease.