Lack of CD47 expression and blockade of CD47 activity by CD47-Fc and CD47 fusion protein (CD47-Var1) can effectively reduce SIRP-alpha+ dendritic cell trafficking into mediastinal lymph node, suppressing Th2 type immune responses in asthma and the expression of IL-1beta and TNF-alpha in patients with Crohn’s disease (20–22). Here, CD47 is linked to Crohn disease.