In addition to the suppressive role of CD47 and SIRP-alpha interaction in tumor cell phagocytosis (29, 37), CD47 and SIRP-alpha interaction can promote trafficking of SIRP-alpha+CD103(-) dendritic cells into mediastinal and mesenteric lymph nodes and driving Th17 and Th2-biased responses. This evidence concerns the gene CD47 and neoplasm.