IL6 and acute respiratory distress syndrome: As a result, we observed that soluble SIRP-alpha in ALI BAL effectively induced the expression of IL-6 and RANTES transcripts in the treated cells, that was effectively reversed by aSIRP pre-treatment (Figure 7B), consistent with the results of immunostaining (Figure 7C) and flow cytometry (Figures 7D, E), in which the expression of TNF-alpha and IL-6 was obviously reduced in BMDMs treated with aSIRP pre-neutralized ALI BAL, compared to the cells treated with IgG-treated controls.