Results revealed significant correlations between cell types: for instance, in core 22 (responders), strong positive spatial correlations between CD4+ T cells (FDR-adjusted p = 2.9845e-7), CD8+ T cells (FDR-adjusted p = 1.0015e-8) and HCC/hepatocytes infiltrations, which may confer an activated antitumor immunity (Figure 4G and Table S4). Here, CD4 is linked to hepatocellular carcinoma.