In contrast, treatment with TRPV1 antagonist capsazepine or TRPV1 siRNA reduced airway hyper-responsiveness (AHR) and airway remodeling with suppressed Th2 cytokines (IL-4, IL-5 and IL-13) and epithelial cell-derived cytokines (TSLP, IL-33, and IL-25) in ovalbumin-induced chronic asthma (60). The gene discussed is TRPV1; the disease is chronic asthma.