The aim of this review is to untangle the complexity of six signal transduction pathways that have been described to be involved in EC responses to sepsis conditions, namely NF-κB, Rac1/RhoA GTPases, AP-1, APC/S1P, Angpt/Tie2, and VEGF/VEGFR2.1 The gene discussed is VEGFA; the disease is Sepsis.