ANGPT2 and Sepsis: Pre-treatment with a neutralising antibody targeting both Angpt2 and VEGF (A2V) in mouse CLP-sepsis alleviated endothelial inflammatory activation in kidney as assessed by reduced intercellular adhesion molecule 1 (ICAM-1) protein expression in peritubular capillaries, reduced pulmonary permeability, and improved 5-day survival (175).