Lupus-prone Lyn-/- mice exhibit intrinsic CD11b dysregulation, with neutrophils showing upregulated CD11b from a pre-disease age (12 weeks) and throughout early- (24 weeks) and late-stage (36 weeks) disease (Supplementary Figure 1A) (22), suggesting that CD11b may contribute to early and ongoing disease processes. This evidence concerns the gene LYN and systemic lupus erythematosus.