However, assessment of renal pathology at 24 weeks of age, which captures early and progressing disease stages, showed that Lyn-/-Itgam-/- mice already exhibited significantly advanced glomerular enlargement (median area 4885 μm, IQR 4198-5849), lobularity and cellular expansion and periglomerular dysplasia (median disease score 2.029, IQR 1.676-2.612) well beyond the mild disease seen in Lyn-/- mice (median glomerular area 3590 μm, IQR 3235-4208; median disease score 0.894, IQR 0.600-1.611) (Figures 2B–D). This evidence concerns the gene LYN and dysplasia.