Systemic indices of autoimmunity and inflammation were also assessed, and at 24 weeks of age, autoantibody titers were significantly elevated in Lyn-/-Itgam-/- mice compared to Lyn-/- mice (Figure 2E), and both splenomegaly (Figure 2F) and lymphadenopathy (Figure 2G) were pronounced in Lyn-/-Itgam-/- mice only. This evidence concerns the gene LYN and Splenomegaly.