ITGAM and systemic lupus erythematosus: In humans, two common SLE-associated CD11b variants from non-synonymous SNPs in the ITGAM locus have been described: R77H (rs1143679) confers an arginine to histidine substitution in the ligand-binding extracellular β propeller region, and P1146S (rs1143683) substitutes proline for serine in the cytoplasmic tail (18).