Increased production of pro-inflammatory cytokines (IL-6, TNF-α, etc.)and chemokines (CXCL1, CXCL10, etc.)intensify hepatic IRI and upregulate the components involved in the progression and metastasis of HCC including angiogenesis cytokines and immunosuppressive cells such as Tregs (35). Here, CXCL10 is linked to hepatocellular carcinoma.