Anti-synthetase syndrome (ASSD) is an autoimmune condition characterized by the presence of autoantibodies directed against an aminoacyl transfer RNA synthetase (aaRS) along with clinical features that include interstitial lung disease (ILD), myositis, Raynaud’s phenomenon, fever, mechanic’s hands, and arthritis (1, 2). The gene discussed is AARS1; the disease is interstitial lung disease.