IDO1 and Graves disease: IFN-g induces the secretion of TrpRS by macrophages, endothelial cells and fibroblasts.High expression in CD4T cells can resist IDO-mediated immunosuppresion from DC in Grave's disease (89).Secretion by monocytes upon infection. Interacts with TLR2/TLR4 leading to the secretion of TNFa and IL-8, neutrophil infiltration and phagocytic abilities (90–92).