TNF and bacterial infectious disease: C-terminal domain: migration of monocytes and stimulation of TNFa. Includes the amino acid sequence Pro344-Ser528 associated with MP and PMN chemotaxis.Truncated mini-TyRS Met1-AsP343: chemoattractant only for PMN.N-terminal: migration of PMNs in a dose dependent manner. Possible functional correlation with IL-8. Can be present in platelets, playin a role in monocyte/macrophage differentiation during bacterial infection (42).