CXCL12 and neoplasm: Once activated, they are sufficient not only to promote tumor growth but also to further model ECM; produce proinflammatory cytokines, proangiogenic VEGF, and the chemokine ligand CXCL12 that is responsible for attracting immunosuppressive cells into TME that indirectly assist in immune tolerance establishment” as this part of the sentence is continuation of the role of CXCL12 (274).