CD8A and hepatocellular carcinoma: An impairment of intra-tumoral CD8+ cell cytotoxic function by HCC intra-tumoral Tregs was also reported (28).The association between high infiltration of Tregs on the one hand, and low infiltration of CD8+ cells on the other hand, coupled with a decreased activity of intra-tumoral CD8+ cells, contribute to the positive correlation between high intra-tumoral Tregs and poor survival in HCC.