noticed a beneficial effect of both tumor-infiltrating Tregs and of the CD8/FoxP3 density ratio on the survival of HSCC patients (14).The simultaneous validity of these two observations can hold only if the positive effect of CD8+ T cells overweighs the negative effect of Tregs on prognosis, considering the opposite effects of the two lymphocytes on tumor growth. This evidence concerns the gene FOXP3 and neoplasm.