In a pooled analysis of HCC studies, high intra-tumoral infiltration of Tregs was associated with a mean HR value of 1.894 (95% CI: 1.658 – 2.164) for overall survival, while high infiltration of CD8+ T cells was associated with a mean HR value of 0.676 (95% CI: 0.540 – 0.845) for overall survival (27). This evidence concerns the gene CD8A and hepatocellular carcinoma.