CD8A and neoplasm: When HR increases with higher frequencies of intra-tumoral Tregs, the two lymphocyte frequencies either inversely correlate with each other (Tregs frequency increases while CD8+ cells frequency decreases) (Cov<1), or they are directly correlated(Cov>1), however in the last scenario Tregs are expected to infiltrate faster than CD8+ T cells into the tumor site, affecting an increase in HR this way.