CD8A and familial pancreatic carcinoma: Table 1 includes 7 types of cancer with HR > 1. In lung adenocarcinoma (17), renal cell carcinoma (21), HCC (28, 29), and pancreatic cancer (32), the frequencies of Tregs and CD8+ (or active CD8+) are inversely correlated. In ovarian cancer (26), and cervical cancer (24) these frequencies are directly correlated. In endometrial cancer, even though the frequencies directly correlate with each other (22), the tumor microenvironment downregulates the activity of CD8+ T cell (23), and the number of active CD8+ T cells plausibly decreases.