In fact, through a neural network analysis of a large cohort of SS patients, the presence of anti-SSA/Ro antibodies turned out to represent a hub, connecting the two main pillars of CV disease phenotypes in SS, i.e. ischemic (such as myocardial o cerebral infarction) and non-ischemic events (such as heart failure) (33, 34). Here, CALR is linked to brain infarction.