However, some reports suggest that the role of anti-SSA/Ro and anti-SSB/La is significant to the point that the rate of cerebral infarction and VTE may be higher compared to the general population (HR = 1.7, 1.0 to 2.9 and 3.1, 1.9 to 4.8, respectively) only in the subgroup of seropositive subjects (32). Here, TRIM21 is linked to brain infarction.