Macrophages from active TB patients exhibited significant downregulation (1.5- 20 fold) of genes encoding glucose transporters 1 and 6 (GLUT1 and 6), glycolytic enzymes/isozymes hexokinases (HK2 and HK3), phosphofructokinase 1 (PFK1), and lactate dehydrogenase A (LDHA) relative to healthy controls (Figure 6D). Here, PFKM is linked to tuberculosis.