It has been evident that reversal of tumor-induced immunosuppression, inhibition of tumor growth, and maximized antitumor responses are achievable through the natural or ionizing radiation-induced secretion of IL-8 that facilitates the intratumoral trafficking of IL-8 receptor-modified CD70-CAR-Ts (IL-8R-CD70-CAR-Ts) (84, 88). The gene discussed is CXCL8; the disease is neoplasm.