TRAF2 and neoplasm: We interrogated tumors without inactivating alterations in TRAF3/CYLD in the NF-κB active group for mutations of genes known to influence the NF-κB pathway; indeed, one tumor contained missense mutation in the MAP3K14 (NIK), and there was a nonsense mutation in the NFκBIA, as well as a nonsense mutation in TRAF2 in two additional tumors (Supplementary Table 5).