ATX antigen levels in ASC patients with pruritus, (median: 665.8 ng/ml, IQR: 357.8–1,203) and in ASC patients without pruritus (median: 391.0 ng/ml, IQR: 283.2–485.6) were not significantly different (p = 0.1061) (Figure 2F). This evidence concerns the gene ENPP2 and Tako-tsubo cardiomyopathy.