FREM1 and congenital diaphragmatic hernia: Because of the observed phenotypic similarities between Frem1-deficient mice and mice lacking the retinoic acid-responsive transcription factor Gata4, the same author group conducted further studies, revealing that Frem1 interacts not only with Gata4 but also with Slit3 in this mouse model of CDH and concomitant lung lobulation defects (128).