Regardless of the titer of anticardiolipin antibody, anticardiolipin antibody can bind to phospholipids on plasma proteins, such as prothrombin, β-2GPI, and V-annexin, and become a risk factor for thrombosis in patients with systemic lupus erythematosus or recurrent abortion [23]. The gene discussed is ANXA5; the disease is systemic lupus erythematosus.