Prior reports also showed the potential of medicinal extracts and natural compounds to improve degeneration of DA neurons in some animal models of PD, for example, black sea cucumber (Holothuria leucospilota) extracts had the potential to notably improve DA neuron degeneration in 6-OHDA-induced worms [31], Scopoletin could recover dopaminergic neural networks and mobility in Drosophila model of PD [40], Ginseng protein prevented mitochondrial dysfunction and neurodegeneration in a fly PINK1 model of PD [41]. Here, PINK1 is linked to Parkinson disease.