As reported in the previous article [36], the change in the external pH environment would cause the transformation of the silk fibroin conformation, resulting in the transformation of the α-helices structure to the β-sheets structure, and the binding force on the AgNPs@AMPs complex was weakened, also the compactness of the coating was weakened, which eventually led to the rapid release of Ag+ to achieve infection-trigger antibacterial ability. The gene discussed is ADSL; the disease is infection.