Recent researches in SOX2 have put emphasis on its key role in stem cell maintenance, lineage fate determination and reprogramming of somatic cells(Sarkar and Hochedlinger 2013).LIN28B, as an RNA-binding protein, selectively inhibit the expression of let-7 miRNA which performs as tumor suppressors and are associated with the downregulation of oncogenes and regulate mitotic pathways including RAS, MYC and HMGA2(Heo et al. 2009; Büssing et al. 2008). This evidence concerns the gene LIN28B and neoplasm.