Meanwhile, in the progression of gastrointestinal tumor, the synergy between NR5A21 and β-catenin/TCF4 signaling upregulate the expression of cyclin D1, cyclin E1, and c-Myc which is the downstream targets of the canonical Wnt signaling (Schoonjans et al. 2005). Here, CCNE1 is linked to digestive system neoplasm.