The synthesis of N-Myc/AR/EZH2-PRC2 complex is notably dependent on the presence of EZH2, and N-MYC shows a remarkable synergistic effect with EZH2 and AR to inhibit AR signaling by methylation, leading to neuroendocrine transformation of prostate cancer (Dardenne et al. 2016) (Fig. 2). Here, MYCN is linked to Familial prostate cancer.