EZH2 and prostate carcinoma: The synthesis of N-Myc/AR/EZH2-PRC2 complex is notably dependent on the presence of EZH2, and N-MYC shows a remarkable synergistic effect with EZH2 and AR to inhibit AR signaling by methylation, leading to neuroendocrine transformation of prostate cancer (Dardenne et al. 2016) (Fig. 2).