Meanwhile, in the progression of gastrointestinal tumor, the synergy between NR5A21 and β-catenin/TCF4 signaling upregulate the expression of cyclin D1, cyclin E1, and c-Myc which is the downstream targets of the canonical Wnt signaling (Schoonjans et al. 2005). This evidence concerns the gene MYC and digestive system neoplasm.