Succinate-CoA ligase (SUCL) is a heterodimeric enzyme composed of a Suclg1 α-subunit and a substrate-specific Suclg2 β-subunit, which generates ATP or GTP respectively, this subunit is able to regulate succinate metabolism and NE differentiation in prostate cancer (Kacso et al. 2016). This evidence concerns the gene SUCLG2 and Familial prostate cancer.