CD4 and gastric cancer: Intriguingly, the CD4/CD8 ratio of T cells in GCs or TDLNs was much higher than that in the PBs (P < 0.001 GCs vs PBs, P < 0.01 TDLNs vs PBs) (Fig. 3A), indicating the presence of local immunosuppression in GCs and TDLNs with relative to system immune status in gastric cancer patients.