Thus, the purpose of this study was to examine the association between hypertension, diabetes, hypercholesterolemia, IHD, and estimated glomerular filtration rate (eGFR) and lead single nucleotide polymorphisms (SNPs) in urate transporter (rs16890979, rs2231142, and rs2078267 in SLC2A9, ABCG2, SLC22A11 respectively) and other genes (rs1260326 and rs1229984 in GCKR and ADH1B, respectively) associated with hyperuricaemia-gout transition. The gene discussed is GCKR; the disease is Hypertension.