According to risk classification criteria developed by the International Neuroblastoma Risk Group (INRG), NB can be categorized into very low‐risk, low‐risk, intermediate‐risk, and high‐risk groups based on the assessment of age at diagnosis, INRG tumor stage, histologic category, grade of differentiation, DNA ploidy, MYCN status, as well as copy number status at chromosome 11q. This evidence concerns the gene MYCN and neuroblastoma.