Evaluation of either single or panels of tumor mRNA transcripts level in the blood (TH, PGP9.5, GALGT, PHOX2B, DDC, DCX, DBH, ELAVL4, CRAMP1, GAP43, ISL1, CHRNA3, KIF1A); Allowing for detecting 1 CTC in 103 PBMCs to 107 PBMCs. This evidence concerns the gene CHRNA3 and neoplasm.