More than four decades of research has contributed multidisciplinary knowledge ranging from the viral infection to human immunity, including, but not limited to, the HIV lifecycle and the role of CD4 T-cells in the host immunity, as well as how HIV maneuvers the host transcriptional machinery, specially releasing a pause of RNA polymerase II (RNAPII) in transcription of the viral RNA [1,2,3]. This evidence concerns the gene CD4 and viral infectious disease.