Thus, patients with COVID-19 showed a decrease in the proportion of EM1 cells with the CD45RA−CD27+CCR7− phenotype, while the relative count of EM2 and EMRA CD8+ T cells (with the CD45RA−CD27−CCR7+ and CD45RA+CD27−CCR7−phenotypes, respectively) significantly increased relative to the control values upon infection with SARS-CoV-2 [57]. The gene discussed is CD8A; the disease is infection.