For example, overexpression of IFI6-16 inhibited genome replication and gene expression of HBV (hepatitis B virus) in HepG2 cells [25], and researchers also found that IFI6-16 could inhibit HCV (hepatitis C virus) infection by impairing EGFR mediated CD81 co-localization with claudin-1 [26]. This evidence concerns the gene CD81 and viral infectious disease.