In the current study, HVEM gene-deficient mice were used, based on the observation of viral infections in mouse JAWSII-dendritic cells, to investigate the interaction between HSV-1 and dendritic cells and the impact of the viral infection of these cells on outcomes after pathologic infection and the immunologic responses involving innate immunity and specific antiviral immunity. This evidence concerns the gene TNFRSF14 and viral infectious disease.