In this study, we determined the antiviral activities of goat IFN-α and IFN-τ against CPIV3 and BPIV3 infection in MDBK cells, and provided experimental evidence that goat IFN-α and IFN-τ are potent to suppress viral replication as a prophylactic but not a treatment for viral infection. The gene discussed is IFNA1; the disease is infection.