Severe acute respiratory coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus 2019 (COVID-19) by binding to angiotensin converting enzyme 2 (ACE2), genetically changes over time, evolving with new mutations generated across the genome, including the spike protein (S-protein) receptor binding domain (RBD) [1,2]. This evidence concerns the gene PROS1 and COVID-19.