CD4 and psychiatric disorder: However, in the non-DTG cohort, the presence of a pre-existing diagnosis of psychiatric disorder (HR 4.15, 95% CI 1.67–10.33, p= 0.002) and higher levels of CD4 + T-cell counts (≥750 cells/mmc, compared to <250 cells/mmc, HR 40.4, 95% CI 1.21–13.44, p= 0.02), mutually adjusted, resulted in predictors of CNS-AE (Table 4).