Strikingly, transient transfection of LGALS1 KO cells with a plasmid encoding LGALS1 48 h prior to infection, by re-establishing Gal-1 protein levels to values similar to those observed in Control cells (Figure 3C: Western blotting analysis), rescued the reduction in H-1PV transduction in these cells (Figure 3C). The gene discussed is LGALS1; the disease is infection.