CD274 and neoplasm: Based on the PD-L1 expression and tumor-infiltrating CD8+ T cell densities, it is recommended to categorize the ICCs into four TME types: Type I (PD-L1+/CD8-High), Type II (PD-L1−/CD8-Low), Type III (PD-L1+/CD8-Low), and Type IV (PD-L1−/CD8-High).