In Thai patients who were naturally infected by DENV, the expression and functionality of TLR7 were suppressed during secondary infections, along with those of TLR3 and TLR4.In vitro studies indicated that infection with DENV in presence of antibody complexes reduced TLR expression suggesting that ADE may suppresses TLR-dependent signaling pathways via Immunoglobulin Fc receptors (FcγRI and FcγRIIa) ligation [132]. This evidence concerns the gene TLR4 and infection.