As a result, the overexpression of Mcl-1 in FAdV-4-infected cells markedly reduced FAdV-4-induced apoptosis in host cells (p < 0.01) (Figure 7A,B), accompanied by reduced expression of viral proteins Hexon and PX in FAdV-4-infected cells (p < 0.01) (Figure 7C–E), indicating that Mcl-1 suppressed FAdV-4-mediated apoptosis, suppressing viral infection. The gene discussed is MCL1; the disease is viral infectious disease.