In this study, the HBV and HCV groups had similar characteristics for those with HCC development, including old age; male gender; higher serum creatinine, total cholesterol, AST, ALT, AFP levels, and APRI and FIB4 scores; and lower platelet counts compared to their non-HCC counterparts (Supplementary Tables S1 and S2). The gene discussed is AFP; the disease is hepatocellular carcinoma.