For example, in lung adenocarcinoma, overexpression of RAP1B induces activation of the Wnt/β-catenin pathway [21], while in colorectal carcinoma, the silencing of RAP1B has an anti-proliferative effect [36], and in esophageal carcinoma, the overexpression of RAP1B is associated with higher levels of proliferation and invasion [37]. Here, RAP1B is linked to carcinoma of esophagus.