Tumours can lead to immunosuppression that favours tumour progression and metastasis and evolves by constitution of an immunosuppressive network, which is mediated by several tumour-derived soluble factors, such as interleukin-10, transforming growth factor-β, and vascular endothelial growth factor, and which extends from the primary tumour site to secondary lymphoid organs and peripheral vessels [62]. This evidence concerns the gene VEGFA and neoplasm.