Another explanation for the absence of severe COVID-19 in adults with PWS could be the beneficial role of oxytocin (OXT), which appears to have special functions in immunologic defense: it suppresses neutrophil infiltration and inflammatory cytokine release, activates T-lymphocytes, and antagonizes the negative effects of ACE2 and other key COVID-19 pathological events [75]. This evidence concerns the gene OXT and Prader-Willi syndrome.