IFITM3 and viral infectious disease: In a previous EPF genome-wide expression study (GWES), several genes involved in the early stages of viral infection were overexpressed in patients with the generalized form of EPF compared to healthy individuals, including IFITM3, APOBEC3A, APOBEC3G, OAS1, OASL, SERINC3, and RPLP2 [40].