Although, especially the TRIM5, TPCN2, EIF4E, EIF4E3, APOBEC3G, P4HB, NUP37, NUP50, NUP88, and TPR genes are crucial in antiviral host responses but show no or at best scarce evidence of involvement in other autoimmune diseases. The gene discussed is EIF4E3; the disease is autoimmune disease.