A haplotype block of eight TRIM5 SNPs within the 5′UTR of the transcript that codes for the TRIM5α isoform (Ensembl accessed 26 November 2021) was associated with lower susceptibility to MS [59]; however, the EPF and MS haplotypes are not associated one with each other (r2 ~ 0.04). Here, TRIM5 is linked to myeloid sarcoma.