Autosomal recessive genetic disorders such as Xeroderma Pigmentosum (XP) and Cockayne Syndrome (CS), are caused by mutations in key mediators of the TC-NER pathway, including XPF, XPG, CSB, etc., that disable the repair of UV-induced DNA damage [61], causing extreme sensitivity to sunlight and increased risk of cutaneous neoplasms. Here, ERCC4 is linked to xeroderma pigmentosum.