Additionally, a recent study by Sinha et al. [128] showed that the circulating antigen-specific antibody-secreting cells (ASCs) that move to lymphoid tissue or specific mucosa site to secrete IgA or IgG antibodies following natural infection or vaccination may also be a good correlate of immune protection against rotavirus in the community, since they appear early and are triggered by all RV strains at high levels during mucosal and systemic infection. The gene discussed is CD79A; the disease is infection.