In contrast, in an ovalbumin mouse model of allergic asthma, a reduction in the ovalbumin-specific Th2 cytokine IL-5 production by lung draining lymph node cells was observed in rBCG::mIL-18-vaccinated mice compared to non-vaccinated or pBCG-vaccinated mice, and this was paralleled by an increase in IFN-γ production by these cells [49]. Here, IL5 is linked to allergic asthma.