IL10 and infection: However, in a follow-up study, TNF-α production by human monocytes was higher after infection with rBCG::PGL-1 than with pBCG, as was the production of IL-12p70 [127], and pre-exposure of the monocytes with rBCG::PGL-1 primed the cells for increased production of IL-1ß and IL-10 by LPS but blocked the induction of VEGF by BCG [127].