These five genes also form signature patterns as new biomarkers and classify COVID-19 patients into seven subgroups coded by involved genes, sub-I (KIAA1614, MND1, SMG1), sub-II (ABCB6, MND1, SMG1), sub-III (RIPK3), sub-IV (ABCB6, KIAA1614, MND1, SMG1), sub-V (KIAA1614, MND1, RIPK3, SMG1), sub-VI (ABCB6, MND1, RIPK3, SMG1), sub-VII (ABCB6, KIAA1614, MND1, SMG1, RIPK3), and heterogeneous populations. The gene discussed is SMG1; the disease is COVID-19.