Furthermore, production of a regulatory cytokine such as IL-10 and TGF-β induce MHC class I chain related-proteins A (MICA) and B (MICB), CD95 and inhibitory enzymes such as Indolamine-2,3-dioxygenase 1 (IDO), by tumor and regulatory cells suppress the activity of NK cells [73]. This evidence concerns the gene IL10 and neoplasm.