TTR and amyloidosis: For example, Onpattro by Alnylam Pharmaceuticals, which is a transthyretin-directed siRNA formulated with LNP for the treatment of polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis), and, of course, the commonly known anti-COVID-19 mRNA vaccines, BNT162b2 by Pfizer/BioNTech and mRNA-1273 by Moderna, although they only received Emergency Use Authorization (EUA) in 2020 [86].