Furthermore, 8-week treatment using a dose of 400 mg/kg of an ethanolic M. charantia extract to streptozotocin-induced diabetic rats resulted in lowered serum glucose and in a reduction of the suppressor of cytokine signaling-3 (SOCS-3), c-Jun N-terminal kinase (JNK) and GLUT-4 content [121], two key players that modulate insulin resistance [122,123]. Here, SOCS3 is linked to Insulin resistance.