Polyvinyl pyrrolidone-based nanogels with acrylic acid grafts conjugated to the amino-terminated AntimiR-31, that targets MiR-31, a microRNA overexpressed by primary and metastatic tissue colon cancer cells (CCR) and target of the E2F2 gene that plays a crucial role in the control of CCR progression. The gene discussed is E2F2; the disease is colonic neoplasm.