Discovered in 1982, the oncogene is an important driver in thyroid carcinogenesis being sufficient for tumour initiation and progression, leading to progressive loss of differentiation markers, such as Tireoglobulin (Tg) and sodium-iodide symporter (NIS) controlling the iodine uptake gradually lost and responsible for iodine refractoriness [19,20]. This evidence concerns the gene SLC5A5 and thyroiditis.